I was mentioning the gamma secretase enzyme around here just the other day as a longstanding target for Alzheimer's therapy.

I'll have the Grand Recommended Med-Chem Book List up later today, but otherwise, blogging will be light over the next few days, what with Thanksgiving and all. A very happy feast to my readers who are celebrating, and hey, those of you in other...

I first published this recipe on the blog a couple of years ago, and I'd like to put it out there again for those readers who will be celebrating Thanksgiving this week. This is a slightly modified version of Craig Claiborne's recipe in the New York...

A comment to yesterday's post made a point that seemed instantly familiar, but it's one that my own thoughts had never quite put together. All of us who do medicinal chemistry came out of academic labs; that's where you get the degrees you need to have...

While I'm putting up odd chemical structures today, I thought I'd add this one, Alasmontamine A, from the latest Organic Letters preprint stream. Natural products scare me: Anyone who wants to take a crack at this one synthetically, you just go right...

While I'm putting up odd chemical structures today, I thought I'd add this one, Alasmontamine A, from the latest Organic Letter preprint stream. Natural products scare me: Anyone who wants to take a crack at this one synthetically, you just go right...