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In the Pipeline

Extensive thoughts on medicine, biochemistry, and the pharmaceutical world.
In the Pipeline Blog  
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The Back Door to the Stock Market

Nov 21, 2008
Nitromed has been in trouble for several years now. They're a perfect example of a dog that caught a car: a company that was demolished by actually getting its drug on the market. No one wanted to...

A Green Fluorescent Nobel Prize

Oct 8, 2008
So it was green fluorescent protein after all! We can argue about whether this was a pure chemistry prize or another quasi-biology one, but either way, the award is a strong one. So, what is the stuff and what's it do? Osamu Shimomura discov...

What Exactly Does Resveratrol Do?

Nov 5, 2009
Resveratrol's a mighty interesting compound. It seems to extend lifespan in yeast and various lower organisms, and has a wide range of effects in mice. Famously, GlaxoSmithKline has expensively bought out Sirtris, a company whose entire research...

Are You Now, Or Have You Ever Been. . .?

Nov 4, 2009
You're supposed to disclose conflicts of interest if you're the author of a scientific paper. For the most part, everyone does, but it's those times that the system breaks down that cause all the trouble. Does this author actually earn a side income...

J&J Raises the Ax

Nov 3, 2009
Johnson & Johnson says that it could be cutting up to 8,000 jobs. This has been in the wind for a while, but I haven't had any reports yet of what it's doing on the ground to the research sites. Any news from the readers affected, or is that yet to...

That Didn't Take Very Long

Nov 3, 2009
Back in late September I wrote about a controversial paper in the Proceedings of the National Academy of Sciences. It attracted comment for its way-out-there hypothesis: that caterpillars and other larvae arose through a spectacular interspecies gene...

In Which You Get to Hear the Phrase "Hatch-Waxman" Again

Nov 2, 2009
There's a constant running battle in the drug industry between the two kinds of pharmaceutical companies: the ones who discover the drugs first, and the ones who sell the drugs cheaply after the patents have expired. It surprises me still how many...

The Back Door to the Stock Market


A Green Fluorescent Nobel Prize



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