Sonic Hedgehog Regulates Ischemia/Hypoxia-Induced Neural Progenitor Proliferation [Original Contributions]

Background and Purpose— Sonic hedgehog (Shh) protein is required for the maintenance of neural progenitor cells (NPCs) in the embryonic and adult hippocampus. Brain ischemia causes increased proliferation of hippocampal NPCs. We therefore examined whether Shh regulates the increase in proliferation of NPCs after ischemia/hypoxia.

Methods— Male SV129 ... Share it

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