... and integrated IP portfolio upon which the company is building its microRNA-based diagnostic and therapeutic discovery engines. ... cell growth may be reduced. About miRviewaC/ ProductsmiRviewaC/ are a series of microRNA-based diagnostic products offered by Rosetta Genomics ... GenomicsRosetta Genomics (Nasdaq: ROSG) is a leading developer of microRNA-based molecular diagnostics. Building on its strong IP ...

... (Vitis vinifera) allowed the identification of many putative conserved microRNA precursors, grouped into multiple gene families. ... deep-sequencing of small RNA fractions can be used both to identify which microRNA precursors are expressed in different tissues and to estimate genomic ... candidate splicing events and approximate primary microRNA transcript coordinates represents a critical first step ...

MicroRNAs are negative regulators of protein coding genes. The liver-specific microRNA-122 (miR-122) is frequently suppressed in primary hepatocellular carcinomas (HCCs). In situ ... 1 receptor (Igf1R) that promote tumorigenesis were validated as targets of miR-122 and were repressed by the microRNA. Conversely, depletion of the endogenous miR-122 in Huh-7 cells facilitated their tumorigenic properties ...

The aberrant expression of several microRNA (miRNA) molecules, which play a crucial role in the regulation of gene expression, has been associated with hepatocarcinogenesis. Now, researchers at the National Cancer Institute, in collaboration with Fudan University, University of Hong Kong, and Ohio State University, have identified a miRNA molecule that could help predict the survival

It remains unclear whether a microRNA (miRNA) affects a given phenotype via concomitant down-regulation of its entire repertoire of targets or instead by suppression of only a modest subset of effectors. We demonstrate that inhibition of breast cancer metastasis by miR-31—a miRNA predicted to modulate >200 mRNAs—can be entirely explained by miR-31's pleiotropic regulation of ...

... that act on double-stranded RNA (ADAR). Recent data suggest that these regulatory processes are connected at a fundamental level. A-to-I editing can affect Drosha processing or directly alter the microRNA (miRNA) sequences responsible for mRNA targeting. Here, we analyzed the previously reported adenosine deaminations occurring in human cDNAs, and asked if there was a relationship between A-to-I ...